Anaspec/生物素-LC-血管紧张素II/5 mg/AS-60276-5
商品编号：
AS-60276-5
品牌：
Anaspec
市场价：
¥5440.00
美元价：
2720.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Biotin - LC - Angiotensin IIBiotin - LC - DRVYIHPF |
| Size | 5 mg |
| Catalog # | AS-60276-5 |
| US$ | $272 |
| Purity | % Peak Area By HPLC ≥ 95% |
This octapeptide Angiotensin II, DRVYIHPF, is biotinylated on the N-terminus via an LC (long chain, also known as 6-Aminohexanoyl, 6-Aminocaproyl or Ahx) linker. It can be used in ELISA assay. Angiotensin II (Ang II) exerts a wide range of effects on the cardiovascular system. It is also implicated in the regulation of cell proliferation, fibrosis and apoptosis. Ang II is formed by cleavage of Ang I by the angiotensin-converting enzyme (ACE) or chymases. Human heart chymase, a chymotrypsin-like serine proteinase, hydrolyzes the Phe8-His9 bond to yield the octapeptide hormone angiotensin II and His-Leu. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | 1, Cobb, C. et al. Gen Comp Endocrinol 127, 8 (2002) 2, Lundequist, A. et al. J Biol Chem 279, 32339 (2004)3, Kinoshita, A. et al. J Biol Chem 266, 19192 (1991) 4, Spyroulias, G. et al. Eur J Biochem 270, 2163 (2003). |
| Molecular Weight | 1385.7 |
| Biotin-LC-DRVYIHPF | |
| Sequence(Three-Letter Code) | Biotin - LC - Asp - Arg - Val - Tyr - Ile - His - Pro - Phe - OH |
| Product Citations | Young, SH. & E. Rozengurt (2006). Qdot nanocrystal conjugates conjugated to bombesin or ANG II label the cognate G protein-coupled receptor in living cells. Am J Physiol-Cell Physiol 290, C728. doi: 10.1152/ajpcell.00310.2005. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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