Anaspec/Angiotensin II, human/5 mg/AS-20633
市场价：
¥680.00
美元价：
340.00
产品分类：
其它动物抗原
公司分类：
Other_animal_antigens
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Name | Angiotensin II, humanDRVYIHPF |
| Size | 5 mg |
| Catalog # | AS-20633 |
| US$ | $34 |
| Purity | % Peak Area By HPLC ≥ 95% |
The octapeptide angiotensin II (Ang II) exerts a wide range of effects on the cardiovascular system. It is also implicated in the regulation of cell proliferation, fibrosis and apoptosis. Ang II is formed by cleavage of Ang I by the angiotensin-converting enzyme (ACE) or chymases. Human heart chymase, a chymotrypsin-like serine proteinase, hydrolyzes the Phe8-His9 bond to yield the octapeptide hormone angiotensin II and His-Leu. | |
| Detailed Information |  Datasheet Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Ref: Cobb, C. et al. Gen. Comp. Endocrinol. 127, 8 (2002); Lundequist, A. et al. J. Biol. Chem. 279, 32339 (2004); Kinoshita, A. et al. J. Biol. Chem. 266, 19192 (1991); Spyroulias, G. et al. Eur. J. Biochem. 270, 2163 (2003). |
| Molecular Weight | 1046.2 |
| DRVYIHPF | |
| Sequence(Three-Letter Code) | H - Asp - Arg - Val - Tyr - Ile - His - Pro - Phe - OH |
| Product Citations | Sargaeva, NP. et al. (2011). Differentiating N-terminal aspartic and isoaspartic acid residues in peptides. Anal Chem 10.1021/ac201223d.Zhang, C. et al. (2011). Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinaseendothelial nitric oxide synthase pathway in rats. Clin Exp Pharmacol Physiol 38, 55. doi: 10.1111/j.1440-1681.2010.05461.x.Badu-Tawaih, A. & Cooks, RG. (2010). Enhanced ion signals in desorption electrospray ionization using surfactant spray solutions. J Am Soc Mass Spectrom 21, 1423.Zhao, Y. et al. (2010). Angiotensin II/angiotensin II type I receptor (AT1R) signaling promotes MCF-7 breast cancer cells survival via PI3-kinase/Akt pathway. J Cell Physiol 225, 168. doi: 10.1002/jcp.22209.Berkout, V. et al. (2009). Fragmentation of Singly Protonated Peptides via Interaction with Metastable Rare Gas Atoms. Anal Chem 81, 725. doi: 10.1021/ac802214e.Kim, J. et al. (2009). Blockade of angiotensin II attenuates VEGF-mediated bloodretinal barrier breakdown in diabetic retinopathy. J Cerebral Blood Flow Metab 29, 621. doi: 10.1038/jcbfm.2008.154. Epub 2008 Dec 24.Rauniyar, N. et al. (2009). Characterization of 4-hydroxy-2-nonenal-modified peptides by liquid chromatography-tandem mass spectrometry using data-dependent acquisition: Neutral loss-driven MS3 versus neutral loss-driven electron capture dissociation. Anal Chem 81, 782. doi: 10.1021/ac802015m.Gardner, M. et al. (2008). Chromogenic cross-linker for the characterization of protein structure by infrared multiphoton dissociation mass spectrometry. Anal Chem 80, 4807. doi: 10.1021/ac800625x.Zhao, Y. et al. (2008). Angiotensin II suppresses adriamycin-induced apoptosis through activation of phosphatidylinositol 3-kinase/Akt signaling in human breast cancer cells. Acta Biochim Biophys Sin 40, 304. doi: 10.1111/j.1745-7270.2008.00402.x.Chipitsyna, G. et al. (2007). Induction of monocyte chemoattractant protein-1 expression by angiotensin II in the pancreatic islets and β-cells. Endocrinology 148, 2198.Zhang, S. et al. (2007). Site-specific Pyrolysis-induced cleavage at aspartic acid residue in peptides and proteins. J Proteome Res 6, 1700. doi: 10.1021/pr060648w.Zhang, S. et al. (2007). On-probe pyrolysis desorption electrospray ionization (DESI) mass spectrometry for the analysis of non-volatile pyrolysis products. J Anal Appl Pyrolysis 80, 353. doi: 10.1016/j.jaap.2007.04.005.Crowe, MC. et al. (2004). Infrared multiphoton dissociation (IRMPD) and collisionally activated dissociationof peptides in a quadrupole ion trapwith selective IRMPD of phosphopeptides. J Am Soc Mass Spectrom 15, 1581. |
品牌介绍
Anaspec阳离子抗菌肽是所有物种先天防御的重要组成部分。在许多生物中，包括真菌，昆虫，两栖动物和人类中，已经鉴定出100多种这些肽。这些疏水性和两亲性肽表现出抗生素，杀真菌，溶血，杀病毒和杀肿瘤活性。基于它们的结构特性，这些抗菌肽可分为三类：螺旋状肽，含有一个至几个二硫键的肽以及富含某些氨基酸（例如脯氨酸或色氨酸）的肽。这些肽大多数具有一些共同的特征，例如它们的低分子量（2-5 kDa），存在多个赖氨酸和精氨酸残基以及两亲性质。尽管尚不清楚它们杀死细菌的确切机制，但已表明导致膜渗透的肽-脂相互作用在其活性中起作用。抗生素肽的实例包括洋甘菊素，其由皮肤的皮肤分泌。非洲爪蟾 ; 人嗜中性粒细胞的防御素和人唾液中的组蛋白。天蚕素是由昆虫在感染条件下产生的。天蚕素A，B和D是紧密的同源物，由天蚕素蛾的35中发现的35-39个残基组成。
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